Chapter 10 Nutritional regulation of hepatic gene expression

摘要: Publisher Summary This chapter presents several important themes that have emerged from the studies concerning regulation of energy homeostasis in response to changing nutritional states mammals. First, changes gene expression, particularly at level transcription, are critical points for adaptive responses organism its environmental conditions. These allow modify enzyme repertoire any cell or tissue meet present needs. The enzymes expressed then subject fine control their activity provide acute metabolic pathways. Second, nutrients themselves, as well hormonal cues, promoting intracellular signaling pathways responsible controlling expression. While signals communication between tissues must coordinate activity, and metabolites provides another regulatory inputs be met ensure appropriate physiological responses. Third, various mechanisms involved transcription factors. Fourth, it should emphasized all factors function regulate metabolically-important proteins work coordinately with many other final levels specific gene.