Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms

摘要: It has long been established that hyperthermia increases the therapeutic benefit of radiation and chemotherapy in cancer treatment. During last few years there have substantial technical improvements sources used to apply measure heat, which greatly enthusiasm for clinical use hyperthermia. These advances are converging with a better understanding physiological molecular effects Therefore, we now at juncture where parameters will influence efficacy treatment can be optimised more systematic rational manner. In addition, novel insights hyperthermia's many biological on tumour cells ultimately result new regimes. For example, essential cellular process DNA repair suggest combination therapies, damage response targeting drugs should clinically explored. Here, provide an overview recent studies various macroscopic microscopic We indicate significance these current treatments how they help design future treatments.