Death and the retrovirus
作者： Jean-Pierre Vartanian , Peter Sommer , Simon Wain-Hobson , None
DOI: 10.1016/J.MOLMED.2003.08.008
关键词:
摘要: Abstract A flurry of new papers has shown that HIV reverse transcription is vulnerable to G→A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism circumvented viral infectivity factor protein, which prevents APOBEC3G from entering virion.
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sci-hub.se 参考文章(21)
Bastien Mangeat, Priscilla Turelli, Gersende Caron, Marc Friedli, Luc Perrin, Didier Trono, Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts Nature. ,vol. 424, pp. 99- 103 ,(2003) , 10.1038/NATURE01709
Miguel Angel Martinez, Monica Sala, Jean-Pierre Vartanian, Simon Wain-Hoboson, Reverse transcriptase and substrate dependence of the RNA hypermutagenesis reaction Nucleic Acids Research. ,vol. 23, pp. 2573- 2578 ,(1995) , 10.1093/NAR/23.14.2573
J. P. Vartanian, A. Meyerhans, M. Sala, S. Wain-Hobson, G-->A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 3092- 3096 ,(1994) , 10.1073/PNAS.91.8.3092
Reuben S Harris, Ann M Sheehy, Heather M Craig, Michael H Malim, Michael S Neuberger, DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses Nature Immunology. ,vol. 4, pp. 641- 643 ,(2003) , 10.1038/NI0703-641
Ann M. Sheehy, Nathan C. Gaddis, Jonathan D. Choi, Michael H. Malim, Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein Nature. ,vol. 418, pp. 646- 650 ,(2002) , 10.1038/NATURE00939
Roberto Mariani, Darlene Chen, Bärbel Schröfelbauer, Francisco Navarro, Renate König, Brooke Bollman, Carsten Münk, Henrietta Nymark-McMahon, Nathaniel R. Landau, Species-Specific Exclusion of APOBEC3G from HIV-1 Virions by Vif Cell. ,vol. 114, pp. 21- 31 ,(2003) , 10.1016/S0092-8674(03)00515-4
Ann Chester, James Scott, Shrikant Anant, Naveenan Navaratnam, RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. Biochimica et Biophysica Acta. ,vol. 1494, pp. 1- 13 ,(2000) , 10.1016/S0167-4781(00)00219-0
D. Lecossier, Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science. ,vol. 300, pp. 1112- 1112 ,(2003) , 10.1126/SCIENCE.1083338
Reuben S Harris, Kate N Bishop, Ann M Sheehy, Heather M Craig, Svend K Petersen-Mahrt, Ian N Watt, Michael S Neuberger, Michael H Malim, DNA deamination mediates innate immunity to (retro)viral infection Cell. ,vol. 113, pp. 803- 809 ,(2003) , 10.1016/S0092-8674(03)00423-9
Hui Zhang, Bin Yang, Roger J. Pomerantz, Chune Zhang, Shyamala C. Arunachalam, Ling Gao, The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA Nature. ,vol. 424, pp. 94- 98 ,(2003) , 10.1038/NATURE01707