Diffuse nodular regenerative hyperplasia of the liver (DNRH). A clinicopathologic study of 24 cases.

摘要: The authors report 24 cases of diffuse nodular regenerative hyperplasia the liver (DNRH) seen in a General Hospital during last 9 years (prevalence: 3'1/100,000, incidence: 0'34/100,000). DNRH was diagnosed 0.52% biopsies and 0.72 autopsies. These results suggest that DNHR is probably more frequent than suspected, 1 for each 39 biopsied cirrhosis. Fourteen patients did not have hepatic symptoms. Portal hypertension present cases. biochemical disturbance most frequently found moderate elevation GGT APh, associated with slight SGOT, SGPT bilirubin levels. Normal function tests could be (3 cases). Previous exposure to potentially hepatotoxic drugs or chemicals discovered 15 (62.5%). Diseases were circulatory disturbances (6 cases), autoimmune disease (5 hemopathies visceral carcinomas (4 Two recipients renal transplant. Nodules distributed through whole tissue 16 cases, while 8 showed areas normal parenchyma their livers. Impairment small vessels detected Some uneven cytologic findings discovered: clusters basophilic cells large clear (8 dysplastic hepatocytes (10 which suggests preneoplastic condition.