Methods of using indazole derivatives as JNK inhibitors

作者: Chris A. Buhr , Steven T. Sakata , Kiran Sahasrabudhe , John Sapienza , Qi Chao

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摘要: Compounds having activity as selective inhibitors of JNK are disclosed. The compounds this invention indazole derivatives the following structure: wherein R1, R2 and A defined herein. Such have utility in treatment a wide range conditions that responsive to inhibition. Thus, methods treating such also disclosed, pharmaceutical compositions containing one or more above compounds.

参考文章(50)
Bruce M Spiegelman, Lisa Choy, Gokhan S Hotamisligil, Reed A Graves, Peter Tontonoz, Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes Journal of Biological Chemistry. ,vol. 268, pp. 6823- 6826 ,(1993) , 10.1016/S0021-9258(18)53107-0
C M Pombo, J V Bonventre, J Avruch, J R Woodgett, J M Kyriakis, T Force, The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. Journal of Biological Chemistry. ,vol. 269, pp. 26546- 26551 ,(1994) , 10.1016/S0021-9258(18)47229-8
Michael J. Birrer, Seth M. Steinberg, Eva Szabo, R. Ilona Linnoila, Maura E. Riffe, Altered cJUN expression: an early event in human lung carcinogenesis. Cancer Research. ,vol. 56, pp. 305- 315 ,(1996)
Ursula A. Germann, Ted Fox, Keith Philip Wilson, Michael Shin-San Su, Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases ,(1999)
Gary S. Firestein, Karlfried R. Aupperle, Brydon Bennett, David L. Boyle, Zuoning Han, Anthony M. Manning, Jun N-Terminal Kinase in Rheumatoid Arthritis Journal of Pharmacology and Experimental Therapeutics. ,vol. 291, pp. 124- 130 ,(1999)
Barry Laine Johnson, James David Rodgers, Haisheng Wang, Indazoles of cyclic ureas useful as hiv protease inhibitors ,(1998)
Diane M. Milne, Linda E. Campbell, David G. Campbell, David W. Meek, p53 Is Phosphorylatedin Vitroandin Vivoby an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1 Journal of Biological Chemistry. ,vol. 270, pp. 5511- 5518 ,(1995) , 10.1074/JBC.270.10.5511
Abdi A Mohit, Joel H Martin, Carol A Miller, p493F12 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system Neuron. ,vol. 14, pp. 67- 78 ,(1995) , 10.1016/0896-6273(95)90241-4