Acute and chronic effects of Δ9-tetrahydrocannabinol on seizures in the gerbil
作者： Martijn Ten Ham , William J. Loskota , Peter Lomax
DOI: 10.1016/0014-2999(75)90087-4
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摘要: Abstract Δ 9 -THC was injected daily for 6 days into gerbils from our breeding colony that exhibit spontaneous epileptiform seizures. At a dose of 20 mg/kg no effect seen on the latency, duration or severity seizures induced after 1 and treatment. (50 mg/kg) completely abolished single injection but tolerance developed to this so protection afforded doses. Severe toxin signs were evident at higher level with marked depression motor activity. The toxic effects increased progressively chronic treatment half animals failed survive.
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