Estrogen-receptor independent effects of two ubiquitous environmental estrogens on Melosira varians Agardh, a common component of the aquatic primary production community.

摘要: Estrogenic compounds have been discovered in many surface water samples anthropogenically altered waters. Wastewater effluent has identified as a major pathway of contamination and found to revert much the metabolic products these biologically active back their original form. This presentation explains methodology for determining exposure effects through newly developed bioassay, examining physiological response diatom compounds. Diatoms represent an important aspect primary production community. They are desirable food source over other members community storage photosynthetically produced sugars form lipids rather than starch. Therefore, higher trophic levels selectively feed on diatoms when present with study examines 17beta-estradiol 4-nonylphenol development species Melosira varians. Clearly, unicellular protists such not susceptible contaminants manner directly analogous that expressed vertebrates. However, estradiol nonylphenol lipophilic making them particularly effective entering cell membrane. varians was selected because it commonly occurs most freshwater environments subject toxicological studies. An adequate literature base also exists evaluating results this experiment. The grows rapidly is easy maintain culture. Comparing density, chl-a, lipid content control exposed cultures allowed interpretation how responded varying compound concentrations. Results revealed differences responses each compound. appears no detrimental effect M. varians, while mortality sufficient dosage. Similar reported autotrophic organism, but uniform photosynthetic groups. use phytoplankton test organism complements investigations involving vertebrate models at or near apex hierarchy by considering web.