Pharmacokinetic evaluation of the vinorelbine–lapatinib combination in the treatment of breast cancer patients

作者: E. Brain , F. Lokiec , Keyvan Rezai , S. Urien , N. Isambert

DOI: 10.1007/S00280-011-1650-8

关键词:

摘要: Purpose The objectives of this study were to investigate the pharmacokinetics intra-venous vinorelbine combined with lapatinib as well effect covariates in breast cancer patients.

参考文章(15)
Vinorelbine – a clinical review British Journal of Cancer. ,vol. 82, pp. 1907- 1913 ,(2000) , 10.1054/BJOC.2000.1203
Laurent Nguyen, Brigitte Tranchand, Christian Puozzo, Philippe Variol, Population pharmacokinetics model and limited sampling strategy for intravenous vinorelbine derived from phase I clinical trials British Journal of Clinical Pharmacology. ,vol. 53, pp. 459- 468 ,(2002) , 10.1046/J.1365-2125.2002.01581.X
Xiao-Jian Zhou, Roger Rahmani, Preclinical and Clinical Pharmacology of Vinca Alkaloids Drugs. ,vol. 44, pp. 1- 16 ,(1992) , 10.2165/00003495-199200444-00002
S. Urien, F. Br�e, F. Breillout, G. Bastian, A. Krikorian, J. P. Tillement, Vinorelbine high-affinity binding to human platelets and lymphocytes: distribution in human blood Cancer Chemotherapy and Pharmacology. ,vol. 32, pp. 231- 234 ,(1993) , 10.1007/BF00685841
Feng Bai, Burgess B. Freeman, Charles H. Fraga, Maryam Fouladi, Clinton F. Stewart, Determination of lapatinib (GW572016) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS). Journal of Chromatography B. ,vol. 831, pp. 169- 175 ,(2006) , 10.1016/J.JCHROMB.2005.11.044
Brian Thiessen, Clinton Stewart, Ming Tsao, Suzanne Kamel-Reid, Paula Schaiquevich, Warren Mason, Jacob Easaw, Karl Belanger, Peter Forsyth, Lynn McIntosh, Elizabeth Eisenhauer, A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation Cancer Chemotherapy and Pharmacology. ,vol. 65, pp. 353- 361 ,(2010) , 10.1007/S00280-009-1041-6
David Khayat, Olivier Rixe, René Brunet, Alain Goupil, Roland Bugat, Jean-Luc Harousseau, Norbert Ifrah, Christian Puozzo, None, Pharmacokinetic linearity of i.v. vinorelbine from an intra-patient dose escalation study design. Cancer Chemotherapy and Pharmacology. ,vol. 54, pp. 193- 205 ,(2004) , 10.1007/S00280-004-0794-1
Karl Brendel, Emmanuelle Comets, Céline Laffont, France Mentré, Evaluation of different tests based on observations for external model evaluation of population analyses Journal of Pharmacokinetics and Pharmacodynamics. ,vol. 37, pp. 49- 65 ,(2010) , 10.1007/S10928-009-9143-7
E. Kuhn, M. Lavielle, Maximum likelihood estimation in nonlinear mixed effects models Computational Statistics & Data Analysis. ,vol. 49, pp. 1020- 1038 ,(2005) , 10.1016/J.CSDA.2004.07.002
John P. Crown, Harold A. Burris, Fran Boyle, Suzanne Jones, Maria Koehler, Beth O. Newstat, Roma Parikh, Cristina Oliva, Alaknanda Preston, Julie Byrne, Steve Chan, Pooled analysis of diarrhea events in patients with cancer treated with lapatinib Breast Cancer Research and Treatment. ,vol. 112, pp. 317- 325 ,(2008) , 10.1007/S10549-007-9860-9