Vinorelbine high-affinity binding to human platelets and lymphocytes: distribution in human blood
作者： S. Urien , F. Br�e , F. Breillout , G. Bastian , A. Krikorian
DOI: 10.1007/BF00685841
关键词: Blood cell 、 Internal medicine 、 Plasma protein binding 、 Platelet 、 Serum albumin 、 Dissociation constant 、 Vinorelbine 、 Albumin 、 Lymphocyte 、 Biochemistry 、 Endocrinology 、 Chemistry
摘要: Using [3H]-vinorelbine, we demonstrated the presence of saturable and time-dependent high-affinity binding sites on human platelets lymphocytes. The dissociation constant binding-site values observed were 200±38 nM, 20.0±2.2 amol/platelet, 155±20 amol/lymphocyte, respectively. Among other blood components, low-affinity vinorelbine to alpha1-acid glycoprotein, serum albumin, lipoproteins was observed. erythocytes nonsaturable. Given relative concentrations these carriers, mainly distributes in platelet compartment (>70%), amount free plasma total is <2%. It suggested that because preferential retention by platelets, variations count are very likely produce changes fraction vinorelbine.
springer.com
sci-hub.se 参考文章(12)
Böyum A, Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 97, pp. 31- 50 ,(1968)
S. Urien, D. Morin, A. Renouard, I. Rocher, J.-P. Tillement, Variation in serum binding of tertatolol mediated by disease-induced modification of alpha-acid glycoprotein concentration. European Journal of Clinical Pharmacology. ,vol. 34, pp. 381- 385 ,(1988) , 10.1007/BF00542440
S. Urien, P. Riant, A. Renouard, B. Coulomb, I. Rocher, J.P. Tillement, Binding of indapamide to serum proteins and erythrocytes Biochemical Pharmacology. ,vol. 37, pp. 2963- 2966 ,(1988) , 10.1016/0006-2952(88)90282-1
Douglas W. Donigian, Richard J. Owellen, Interaction of vinblastine, vincristine and colchicine with serum proteins Biochemical Pharmacology. ,vol. 22, pp. 2113- 2119 ,(1973) , 10.1016/0006-2952(73)90110-X
Sigurd G. Vitols, Michele Masquelier, Curt O. Peterson, Selective uptake of a toxic lipophilic anthracycline derivative by the low-density lipoprotein receptor pathway in cultured fibroblasts. Journal of Medicinal Chemistry. ,vol. 28, pp. 451- 454 ,(1985) , 10.1021/JM00382A011
Ilona Fitos, Julia Visy, Miklós Simonyi, Binding of vinca alkaloid analogues to human serum albumin and to α1-acid glycoprotein Biochemical Pharmacology. ,vol. 41, pp. 377- 383 ,(1991) , 10.1016/0006-2952(91)90534-C
W. H. Steele, D. J. King, H. E. Barber, G. M. Hawksworth, A. A. Dawson, J. C. Petrie, The Protein Binding of Vinblastine in the Serum of Normal Subjects and Patients with Hodgkin's Disease European Journal of Clinical Pharmacology. ,vol. 24, pp. 683- 687 ,(1983) , 10.1007/BF00542223
Michèle Masquelier, Sigurd Vitols, Curt Peterson, Low-density lipoprotein as a carrier of antitumoral drugs: in vivo fate of drug-human low-density lipoprotein complexes in mice. Cancer Research. ,vol. 46, pp. 3842- 3847 ,(1986)
Robert O. Mulhausen, Poul Astrup, Kresten Mellemgaard, Oxygen Affinity and Acid-Base Status of Human Blood during Exposure to Hypoxia and Carbon Monoxide Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 21, pp. 9- 15 ,(1968) , 10.1080/00365516809168026
Peter W. Gout, Lynda L. Wijcik, Charles T. Beer, Differences between vinblastine and vincristine in distribution in the blood of rats and binding by platelets and malignant cells European Journal of Cancer (1965). ,vol. 14, pp. 1167- 1178 ,(1978) , 10.1016/0014-2964(78)90222-0