Endometriosis and Risk of Coronary Heart Disease

摘要: Background― Endometriosis is a prevalent gynecologic disease associated with systemic chronic inflammation, heightened oxidative stress, and atherogenic lipid profile that may increase women’s risk for coronary heart (CHD). Methods Results― We examined the prospective association between laparoscopically confirmed endometriosis subsequent CHD among 116 430 women in Nurses’ Health Study II (1989–2009). Participants history of stroke were excluded. When compared without endometriosis, had higher myocardial infarction (relative risk, 1.52; 95% confidence interval, 1.17–1.98), angiographically angina (1.91; 1.59–2.29), artery bypass graft surgery/coronary angioplasty procedure/stent (1.35; 1.08–1.69), or any these end points combined (1.62; 1.39–1.89), independent potential demographic, anthropometric, family history, reproductive, lifestyle confounders. Relative point was highest aged ≤40 years (3.08; 2.02–4.70) decreased as age increased (40 55 years, 0.98; 0.56–1.72; P value, test heterogeneity=0.001). Having hysterectomy/oophorectomy not having (1.51; 1.34–1.71). A percentage 42 could be explained by greater frequency earlier at surgery after diagnosis. Conclusions― In this large, cohort, CHD. The strongest young women. Hysterectomy/oophorectomy partially explain