Multiscale modeling of the ErbB receptor tyrosine kinase signaling network through theory and experiment

K. W. Thiel, G. Carpenter, Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 19238- 19243 ,(2007) , 10.1073/PNAS.0703854104

Manuela Vecchi, Josep Baulida, Graham Carpenter, Selective Cleavage of the Heregulin Receptor ErbB-4 by Protein Kinase C Activation Journal of Biological Chemistry. ,vol. 271, pp. 18989- 18995 ,(1996) , 10.1074/JBC.271.31.18989

Lisa M Shewchuk, Anne M Hassell, Byron Ellis, W.D Holmes, Roderick Davis, Earnest L Horne, Sue H Kadwell, David D McKee, John T Moore, Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. Structure. ,vol. 8, pp. 1105- 1113 ,(2000) , 10.1016/S0969-2126(00)00516-5

Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'meara, Raffaella Smith, Adrian Parker, Andy Barthorpe, Matthew Blow, Lisa Brackenbury, Adam Butler, Oliver Clarke, Jennifer Cole, Ed Dicks, Angus Dike, Anja Drozd, Ken Edwards, Simon Forbes, Rebecca Foster, Kristian Gray, Chris Greenman, Kelly Halliday, Katy Hills, Vivienne Kosmidou, Richard Lugg, Andy Menzies, Janet Perry, Robert Petty, Keiran Raine, Lewis Ratford, Rebecca Shepherd, Alexandra Small, Yvonne Stephens, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S Cooper, Adrienne M Flanagan, Margaret Knowles, Suet Y Leung, David N Louis, Leendert HJ Looijenga, Bruce Malkowicz, Marco A Pierotti, Bin Teh, Georgia Chenevix-Trench, Barbara L Weber, Siu T Yuen, Grace Harris, Peter Goldstraw, Andrew G Nicholson, P Andrew Futreal, Richard Wooster, Michael R Stratton, None, Intragenic ERBB2 kinase mutations in tumours Nature. ,vol. 431, pp. 525- 526 ,(2004) , 10.1038/431525B

James Griffith, James Black, Carlos Faerman, Lora Swenson, Michael Wynn, Fan Lu, Judith Lippke, Kumkum Saxena, The Structural Basis for Autoinhibition of FLT3 by the Juxtamembrane Domain Molecular Cell. ,vol. 13, pp. 169- 178 ,(2004) , 10.1016/S1097-2765(03)00505-7

Monica Red Brewer, Sung Hee Choi, Diego Alvarado, Katarina Moravcevic, Ambra Pozzi, Mark A. Lemmon, Graham Carpenter, The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain Molecular Cell. ,vol. 34, pp. 641- 651 ,(2009) , 10.1016/J.MOLCEL.2009.04.034

Satoshi Yamada, Satoru Shiono, Akiko Joo, Akihiko Yoshimura, Control mechanism of JAK/STAT signal transduction pathway. FEBS Letters. ,vol. 534, pp. 190- 196 ,(2003) , 10.1016/S0014-5793(02)03842-5

A. P. Kornev, S. S. Taylor, L. F. Ten Eyck, A helix scaffold for the assembly of active protein kinases Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 14377- 14382 ,(2008) , 10.1073/PNAS.0807988105

Xiaomin Chen, Uwe Vinkemeier, Yanxiang Zhao, David Jeruzalmi, James E. Darnell, John Kuriyan, Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. ,vol. 93, pp. 827- 839 ,(1998) , 10.1016/S0092-8674(00)81443-9

Rajanikanth Vadigepalli, Praveen Chakravarthula, Daniel E. Zak, James S. Schwaber, Gregory E. Gonye, PAINT: A Promoter Analysis and Interaction Network Generation Tool for Gene Regulatory Network Identification OMICS: A Journal of Integrative Biology. ,vol. 7, pp. 235- 252 ,(2003) , 10.1089/153623103322452378