Intragenic ERBB2 kinase mutations in tumours

摘要: The protein-kinase family is the most frequently mutated gene found in human cancer and faulty kinase enzymes are being investigated as promising targets for design of antitumour therapies. We have sequenced encoding transmembrane protein tyrosine ERBB2 (also known HER2 or Neu) from 120 primary lung tumours identified 4% that mutations within domain; adenocarcinoma subtype cancer, 10% cases had mutations. inhibitors, which so far proved to be ineffective treating should now clinically re-evaluated specific subset patients with whose carry