EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

作者: J Guillermo Paez , Pasi A Janne , Jeffrey C Lee , Sean Tracy , Heidi Greulich

DOI: 10.1126/SCIENCE.1099314

关键词:

摘要: … cytotoxic therapy with or without gefitinib revealed no survival benefit for the gefitinib-treated NSCLC patients (24, 25), our current data suggest that gefitinib may be particularly effective …

参考文章(25)
V. Rusch, Ethan Dmitrovsky, C. Cordon-Cardo, S. Hoda, M. Zaman, Jonathan M Kurie, J. Mcintosh, J. Baselga, J. Orazem, Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung Cancer Research. ,vol. 53, pp. 2379- 2385 ,(1993)
H Yamazaki, Y Fukui, Y Ueyama, N Tamaoki, T Kawamoto, S Taniguchi, M Shibuya, Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors. Molecular and Cellular Biology. ,vol. 8, pp. 1816- 1820 ,(1988) , 10.1128/MCB.8.4.1816
Pasi A. Jänne, Sarada Gurubhagavatula, Beow Y. Yeap, Joan Lucca, Patricia Ostler, Arthur T. Skarin, Panos Fidias, Thomas J. Lynch, Bruce E. Johnson, Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839, ‘Iressa’) on an expanded access study Lung Cancer. ,vol. 44, pp. 221- 230 ,(2004) , 10.1016/J.LUNGCAN.2003.12.014
Takashi Fujishita, Massimo Loda, Ross E. Turner, Marinshine Gentler, Tatsuhiko Kashii, Oscar S. Breathnach, Bruce E. Johnson, Sensitivity of Non-Small-Cell Lung Cancer Cell Lines Established from Patients Treated with Prolonged Infusions of Paclitaxel Oncology. ,vol. 64, pp. 399- 406 ,(2003) , 10.1159/000070299
Morgan Huse, John Kuriyan, The Conformational Plasticity of Protein Kinases Cell. ,vol. 109, pp. 275- 282 ,(2002) , 10.1016/S0092-8674(02)00741-9
Mercedes E Gorre, Mansoor Mohammed, Katharine Ellwood, Nicholas Hsu, Ron Paquette, P Nagesh Rao, Charles L Sawyers, Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification Science. ,vol. 293, pp. 876- 880 ,(2001) , 10.1126/SCIENCE.1062538
Christopher D.M. Fletcher, Heikki Joensuu, George D. Demetri, Margaret von Mehren, Charles D. Blanke, Annick D. Van den Abbeele, Burton Eisenberg, Peter J. Roberts, Michael C. Heinrich, David A. Tuveson, Samuel Singer, Milos Janicek, Jonathan A. Fletcher, Stuart G. Silverman, Sandra L. Silberman, Renaud Capdeville, Beate Kiese, Bin Peng, Sasa Dimitrijevic, Brian J. Druker, Christopher Corless, Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. The New England Journal of Medicine. ,vol. 347, pp. 472- 480 ,(2002) , 10.1056/NEJMOA020461
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938
A. Jemal, R. C. Tiwari, T. Murray, A. Ghafoor, A. Samuels, E. Ward, E. J. Feuer, M. J. Thun, Cancer Statistics, 2004 CA: A Cancer Journal for Clinicians. ,vol. 54, pp. 8- 29 ,(2004) , 10.3322/CANJCLIN.54.1.8
Giuseppe Giaccone, Roy S. Herbst, Christian Manegold, Giorgio Scagliotti, Rafael Rosell, Vincent Miller, Ronald B. Natale, Joan H. Schiller, Joachim von Pawel, Anna Pluzanska, Ulrich Gatzemeier, John Grous, Judith S. Ochs, Steven D. Averbuch, Michael K. Wolf, Pamela Rennie, Abderrahim Fandi, David H. Johnson, Gefitinib in Combination With Gemcitabine and Cisplatin in Advanced Non–Small-Cell Lung Cancer: A Phase III Trial—INTACT 1 Journal of Clinical Oncology. ,vol. 22, pp. 777- 784 ,(2004) , 10.1200/JCO.2004.08.001