Relationship between CD4+ T-cell counts/HIV-1 RNA plasma viral load and AIDS-defining events among persons followed in the ACTG longitudinal linked randomized trials study.

摘要: Background: AIDS-defining events (ADEs) decreased in the era of highly active antiretroviral therapy but still lead to hospitalizations and deaths. Understanding factors related ADEs is important mitigate events. Methods: We examined relationship between demographics, behaviors, comorbidities, laboratory, clinical measurements, diagnosed among subjects randomized treatments (ART)/strategies followed prospectively. Logistic regression models using generalized estimating equations generated odds ratios (ORs) focusing on current CD4 + T-cell count (CD4)/HIV-1 RNA viral load (VL) subsequent 16-week study period. Results: Among 2948 analysis, overall incidence was 1.53 per 100 person-years. Multivariate adjusted for body mass index, ADE history. A 6-level time-varying variable VL (> 100,000 copies/mL, ≤100,000) at levels (0-50, 51-200, >200 cells/μL); reference level >200/VL ≤100,000. ART naives, having an interval were greater with lower counts; this modified by (CD4 ≤50/VL > 100,000: OR 37.2; ≤100,000: 30.5; 51-200/VL 13.0; 4.5; all P values <0.001). Similar results seen ART-experienced subjects. Conclusions: Recent are closely associated development even after examining a multitude potential factors.