Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: A 20-year cohort study

摘要: Cancers such as Kaposi’s sarcoma (KS) were among the initial clinical diagnoses that led to recognition of human immunodeficiency virus (HIV) infections in 1981 [1]. Some experts 1980s suggested malignancies would cause a second epidemic, which was realized with occurrence KS and lymphoma [2]. Subsequently, three cancers classified AIDS-defining (ADCs), including KS, non-Hodgkin’s (NHL), invasive cervical carcinoma (ICC) [3, 4]. With advent highly active antiretroviral therapy (HAART) 1996, rates NHL central nervous system have dramatically fallen, less effect on ICC systemic [5-10]. Simultaneously, non-AIDS-defining (NADCs) accounted for an increasing proportion cancer cases reported HIV-infected individuals. Recent studies NADCs represented 13% deaths during HAART era, compared than 1% pre-HAART era [11], fatal are now more common ADCs [12]. However, other research has shown conflicting results regarding incidence [13, 14]. Further evaluation trends large diverse HIV positive cohorts include early-stage patients is needed. We evaluated prospectively collected data from 23-year observational Tri-Service AIDS Clinical Consortium (TACC) Natural History Study (NHS) further investigate persons. Further, given availability individual patient data, we assessed whether CD4 cell counts, viral loads, or medications predictors