Injectable PLGA Systems for Delivery of Vaccine Antigens

摘要: Micro and nanoparticles prepared from poly (lactic-co-glycolic acid) (PLGA) polymer represent a unique promising delivery system for vaccine antigens. Administration of PLGA with adsorbed or encapsulated antigens has been shown to improve immunogenic responses in mammals relative administration soluble antigen. microparticles are capable delivering number agents simultaneously presenting multiple copies on the surface, both which lead stronger activation signal. can also trap retain local lymph nodes protect them ­proteolytic ­degradation, ensuring longer stimulation by Since ­interior is not “friendly” environment most proteins, each protein ­antigen requires careful optimization. Over last 10 years, significant advances antigen stabilization have made. It expected that first clinical use this dosage form vaccines will be treatment diseases such as cancer instead prophylactic immunization healthy populations.