Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategies.

摘要: Abstract— Population stratification, secondary effects of illness or treatment, biological heterogeneity a clinical syndrome, complex biology underlying syndrome (where only one component is measured) are conditions which may obscure the association genetic risk factor with syndrome. We consider several investigative strategies under each these conditions. Only segregation-based paradigms robust to and population stratification. But on produced by treatment require other for their detection.