A general approach to describe the antimicrobial agent release from highly swellable films intended for food packaging applications.
作者： G.G. Buonocore , M.A. Del Nobile , A. Panizza , M.R. Corbo , L. Nicolais
DOI: 10.1016/S0168-3659(03)00154-8
关键词:
摘要: A mathematical model able to describe the release kinetics of antimicrobial agents from crosslinked polyvinylalcohol (PVOH) into water is presented. The was developed by taking account diffusion molecules polymeric film, counter-diffusion incorporated agent film water, and matrix swelling kinetic. To validate sorption as well three (i.e., lysozyme, nisin sodium benzoate, all approved be used in contact with food) were determined at ambient temperature (25 °C). investigated active entrapped four films PVOH a different degree crosslink. successfully fit above sets data, corroborating validity hypothesis made derive it.
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DONGHWAN CHUNG, MICHAEL L. CHIKINDAS, KIT L. YAM, Inhibition of Saccharomyces cerevisiae by slow release of propyl paraben from a polymer coating. Journal of Food Protection. ,vol. 64, pp. 1420- 1424 ,(2001) , 10.4315/0362-028X-64.9.1420
Ronald S. Harland, Andrea Gazzaniga, M. Edvige Sangalli, Paolo Colombo, Nikolaos A. Peppas, Drug/Polymer Matrix Swelling and Dissolution Pharmaceutical Research. ,vol. 5, pp. 488- 494 ,(1988) , 10.1023/A:1015913207052
John Crank, The mathematics of diffusion ,(1956)
Nicholas A. Peppas, Hydrogels in Medicine and Pharmacy ,(1987)
W Liu, J N Hansen, Some chemical and physical properties of nisin, a small-protein antibiotic produced by Lactococcus lactis. Applied and Environmental Microbiology. ,vol. 56, pp. 2551- 2558 ,(1990) , 10.1128/AEM.56.8.2551-2558.1990
REINALDO BOQUET, JORGE CHIRIFE, HÉCTOR A. IGLESIAS, Equations for fitting water sorption isotherms of foods International Journal of Food Science and Technology. ,vol. 13, pp. 319- 327 ,(1978) , 10.1111/J.1365-2621.1978.TB00809.X
M.A. Del Nobile, G. Mensitieri, P.A. Netti, L. Nicolais, Anomalous diffusion in poly-ether-ether-ketone Chemical Engineering Science. ,vol. 49, pp. 633- 644 ,(1994) , 10.1016/0009-2509(94)85009-7
U. Conte, P. Colombo, A. Gazzaniga, M.E. Sangalli, A. La Manna, Swelling-activated drug delivery systems. Biomaterials. ,vol. 9, pp. 489- 493 ,(1988) , 10.1016/0142-9612(88)90043-9
Harry M. Pylypiw, Maureen T. Grether, Rapid high-performance liquid chromatography method for the analysis of sodium benzoate and potassium sorbate in foods Journal of Chromatography A. ,vol. 883, pp. 299- 304 ,(2000) , 10.1016/S0021-9673(00)00404-0
Takeru Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension Journal of Pharmaceutical Sciences. ,vol. 50, pp. 874- 875 ,(1961) , 10.1002/JPS.2600501018