Loci controlling lymphocyte production of interferon γ after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility
作者： Marie Lipoldová , Helena Havelková , Jana Badalová , Jarmila Vojtíšková , Lei Quan
DOI: 10.1007/S00262-009-0739-Y
关键词:
摘要: Low infiltration of lymphocytes into cancers is associated with poor prognosis, but the reasons why some patients exhibit a low and others high tumors are unknown. Previously we mapped four loci (Lynf1–Lynf4) controlling lymphocyte mouse lung tumors. These do not encode any molecules that involved in traffic lymphocytes. Here report genetic relationship between these control production IFNγ allogeneic mixed cultures (MLC). We found by O20/A mice lower than OcB-9/Dem (both H2pz) stimulated MLC irradiated splenocytes C57BL/10SnPh (H2b) or BALB/cHeA (H2d) mice, ConA. MLCs individual (O20 × OcB-9)F2 C57BL/10 genotyped for microsatellite markers revealed IFNγ-controlling (Cypr4-Cypr7), each which closely linked one Lynf cluster susceptibility genes different This suggests inherited differences certain responses may modify their propensity to infiltrate capacity affect tumor growth.
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