CTL-Assays for Functional Testing of Bispecific Antibody Fragments
作者： Anja Löffler , Torsten Dreier , Ralf C. Bargou
DOI: 10.1007/978-3-662-04605-0_45
关键词:
摘要: Bispecific antibody fragments, designed as therapeutic agents for the treatment of neoplastic diseases, usually combine binding regions antibodies against a specific antigen on target cell with an site surface molecules effector cells immune system such NK or T lymphocytes. The establishment appropriate in vitro assays determination lysis by cells, activated these molecules, are absolutely crucial functional testing. choice this assay mainly depends nature and availability technical equipment available (e.g. opportunity to work radioactively labelled material).
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