Penicillin-Susceptible Group B Streptococcal Clinical Isolates with Reduced Cephalosporin Susceptibility
作者： Noriyuki Nagano , Yukiko Nagano , Masami Toyama , Kouji Kimura , Keigo Shibayama
DOI: 10.1128/JCM.01291-14
关键词:
摘要: We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTB(r) PSGBS). The CTB(r) PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared T394A substitution in penicillin-binding protein 2X (PBP 2X) T567I PBP 2B, together with an additional G429S or T145A 1A, although the transglycosidase domain 1A would have effect on level resistance to ceftibuten.
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