Molecular Identities of Two Tetrodotoxin-Resistant Sodium Channels in Corneal Axons

摘要: Abstract Previous electrophysiological studies have demonstrated that tetrodotoxin-resistant (TTX-R) sodium channels contribute to action potential electrogenesis and conduction along non-myelinated PNS axons. Moreover, recent work has established TTX-R play a major role in the generation of potentials terminals nociceptive axons innervating cornea. We utilized subtype-specific antibodies Na v 1.8 1.9 examine molecular identity are present these Both expressed diffusely entire lengths corneal axons, from nerve plexus at corneoscleral limbus distal leash fibers. both localized bulb-like fibers within superficial epithelial layers These observations suggest