Elevated salivary EGF levels stimulated by periodontal surgery.

摘要: Previous studies have shown epidermal growth factor (EGF) to be involved in oral wound healing as well gastric cytoprotection. EGF functions with hormone-like properties stimulate epithelial cells by binding the receptor which ultimately leads proliferation via signal transduction mechanisms. Salivary glands are a major source of EGF. The purpose this study was determine if intra-oral wounding periodontal surgery stimulated increased salivary levels. levels were determined for 12 systemically healthy individuals (ages 27 70 years old) presurgically and postsurgically at 6, 12, 18, 24, 30, 36, 42 hours 2 6 weeks. Three ml unstimulated whole saliva obtained each time point allow immunoassay quantitation. Age gender matched unoperated patients served controls. samples incubated monoclonal polyclonal antibodies these “sandwich” enzyme immunoassays. Quantitation spectrometric analysis O...