The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats—A comparative study
作者： František Bárta , Kateřina Levová , Eva Frei , Heinz H. Schmeiser , Volker M. Arlt
DOI: 10.1016/J.MRGENTOX.2014.01.012
关键词:
摘要: Abstract Aristolochic acid is the cause of aristolochic nephropathy (AAN) and Balkan endemic (BEN) their associated urothelial malignancies. Using Western blotting, we investigated expression NAD(P)H:quinone oxidoreductase (NQO1), most efficient cytosolic enzyme that reductively activates I (AAI) in mice rats. In addition, effect AAI on NQO1 protein its enzymatic activity these experimental animal models was examined. We found levels fractions isolated from liver, kidney lung differed those expressed organs mice, highest were kidney, followed by liver. contrast, lowest rat-kidney cytosol, whereas amounts cytosols, induced liver AAI-pretreated compared with untreated mice. also rat AAI. Furthermore, increase hepatic renal bio-activation elevated AAI-DNA adduct ex vivo incubations DNA conclusion, our results indicate can own metabolic activation inducing NQO1, thereby enhancing genotoxic potential.
core.ac.uk
sci-hub.se 参考文章(58)
Stiborova M, Jerabek P, Martinek, Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1. Neuro endocrinology letters. pp. 25- 32 ,(2012)
Marie Stiborova, Frantisek Barta, Heinz H Schmeiser, Katerina Levova, Jaroslav Mares, Jana Pavlickova, Petr Hodek, Eva Frei, Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver. Neuro endocrinology letters. pp. 121- 130 ,(2011)
Lars Ernster, [56] DT diaphorase Methods in Enzymology. ,vol. 10, pp. 309- 317 ,(1967) , 10.1016/0076-6879(67)10059-1
Marie Stiborova, Jiri Hudecek, Heinz H Schmeiser, Volker M Arlt, Vaclav Martinek, Bozena Kubickova, Eva Frei, Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases. Neuro endocrinology letters. ,vol. 32, pp. 57- 70 ,(2011)
Marie Stiborovà, Heinz H Schmeiser, Volker M Arlt, Chemical and molecular basis of the carcinogenicity of Aristolochia plants. Current Opinion in Drug Discovery & Development. ,vol. 12, pp. 141- 148 ,(2009)
Jill E. Kucab, David H. Phillips, Volker M. Arlt, Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model. FEBS Journal. ,vol. 277, pp. 2567- 2583 ,(2010) , 10.1111/J.1742-4658.2010.07676.X
J P Cosyns, H H Schmeiser, C A Bieler, M Wiessler, C van Ypersele de Strihou, Detection of DNA Adducts Formed by Aristolochic Acid in Renal Tissue from Patients with Chinese Herbs Nephropathy Cancer Research. ,vol. 56, pp. 2025- 2028 ,(1996)
U. Mengs, C. D. Stotzem, Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology Archives of Toxicology. ,vol. 67, pp. 307- 311 ,(1993) , 10.1007/BF01973700
Graham M. Lord, Monica Hollstein, Volker M. Arlt, Candice Roufosse, Charles D. Pusey, Terry Cook, Heinz H. Schmeiser, DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy American Journal of Kidney Diseases. ,vol. 43, pp. e18.1- e18.7 ,(2004) , 10.1053/J.AJKD.2003.11.024
Marie Stiborová, Eva Frei, Volker M. Arlt, Heinz H. Schmeiser, Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy. Mutation Research-reviews in Mutation Research. ,vol. 658, pp. 55- 67 ,(2008) , 10.1016/J.MRREV.2007.07.003