Spindle cell carcinoma of the nasal cavity

摘要: We report an extremely rare case of spindle cell carcinoma the sinonasal cavity. A 75-year-old man was admitted to our hospital because right nasal obstruction. Nasal endoscopy showed a polypoid tumor measuring 3 × cm at septum in cavity, and excisional biopsy performed. Computed tomography (CT) demonstrated extended maxillary sinus. Histologically, consisted malignant cells with hyperchromatic nuclei. Mitotic figures necrosis were recognized. In some areas, edematous changes No apparent differentiation noted. The free keratinization intercellular bridge formations; therefore, there no squamous components. Immunohistochemically, positive for pancytokeratin, cytokeratin (CK)5/6, CK18, CK19, high molecular weight CK, p63, vimentin. negative epithelial membrane antigen, CK7, CK14, p53 protein, S100 HMB45, chromogranin, synaptophysin, CD34, CD56, glial fibrillary acidic neuron-specific enolase, neurofilaments, α-smooth muscle actin, neuroblastoma, myoglobin, carcinoembryonic antigen (CEA), carbohydrate (CA)19-9, CD3, CD20, CD30, CD45RO, CD45. pathological diagnosis lesion made. patient underwent resection maxilla followed by chemotherapy radiation alive without metastasis 5 years after initial presentation.