Myelodysplastic syndromes following therapy with hypomethylating agents (HMAs): development of acute erythroleukemia may not influence assessment of treatment response
作者： Jie Peng , Robert P. Hasserjian , Guilin Tang , Keyur P. Patel , Maitrayee Goswami
DOI: 10.3109/10428194.2015.1079318
关键词:
摘要: This study followed 28 patients with myelodysplastic syndromes (MDS) who showed a rise of bone marrow (BM) erythroids to ≥ 50% following three cycles (1-60) hypomethylating agent (HMA) therapy. If BM blasts were calculated as percentage non-erythroids, 12 (42.9%) met the diagnostic criteria for acute erythroleukemia, erythroid/myeloid (AEL). However, none clonal cytogenetic evolution or new mutations. When compared to 47 de novo AEL patients, these less anemic and thrombocytopenic, had complex karyotypes (p = 0.044) longer survival, either from diagnosis (p < 0.001) time (p = 0.005). These findings illustrate that ≥ 50% may appear in post-HMA therapy, likely combination reduction granulocytes promotion normal abnormal erythroid proliferation. Enumeration non-erythroid cells lead mis-interpretation disease progression.
sci-hub.se 参考文章(34)
Demakos Ep, Schiffer C, Davis Rb, Silverman Lr, Alter Bp, Cornell Cj, Ellison Rr, Holland Jf, Carey Rw, Weinberg Rs, Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia. ,vol. 7, pp. 21- 29 ,(1993)
Peter Greenberg, Christopher Cox, Michelle M. LeBeau, Pierre Fenaux, Pierre Morel, Guillermo Sanz, Miguel Sanz, Teresa Vallespi, Terry Hamblin, David Oscier, Kazuma Ohyashiki, Keisuke Toyama, Carlo Aul, Ghulam Mufti, John Bennett, International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes Blood. ,vol. 89, pp. 2079- 2088 ,(1997) , 10.1182/BLOOD.V89.6.2079
Marotta G, De Angelis, Sardeo G, Pinto A, Gattei, Lo Re G, Zagonel, Monfardini S, Babare R, 5-Aza-2'-deoxycytidine (Decitabine) induces trilineage response in unfavourable myelodysplastic syndromes. Leukemia. ,vol. 7, pp. 30- 35 ,(1993)
Juan Ouyang, Maitrayee Goswami, Guilin Tang, Jie Peng, Farhad Ravandi, Naval Daver, Mark Routbort, Sergej Konoplev, Pei Lin, L. Jeffrey Medeiros, Jeffrey L. Jorgensen, Sa A. Wang, The clinical significance of negative flow cytometry immunophenotypic results in a morphologically scored positive bone marrow in patients following treatment for acute myeloid leukemia American Journal of Hematology. ,vol. 90, pp. 504- 510 ,(2015) , 10.1002/AJH.23988
Sa A Wang, Guilin Tang, Oluwole Fadare, Suyang Hao, Azra Raza, Bruce A Woda, Robert P Hasserjian, Erythroid-predominant myelodysplastic syndromes: enumeration of blasts from nonerythroid rather than total marrow cells provides superior risk stratification. Modern Pathology. ,vol. 21, pp. 1394- 1402 ,(2008) , 10.1038/MODPATHOL.2008.142
Wei-Lien Wang, Empar Mayordomo, Bogdan A Czerniak, Lynne V Abruzzo, Paola Dal Cin, Dejka M Araujo, Dina C Lev, Dolores López-Terrada, Alexander JF Lazar, Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma Modern Pathology. ,vol. 21, pp. 1303- 1310 ,(2008) , 10.1038/MODPATHOL.2008.114
Petter S Woll, Una Kjällquist, Onima Chowdhury, Helen Doolittle, David C Wedge, Supat Thongjuea, Rikard Erlandsson, Mtakai Ngara, Kristina Anderson, Qiaolin Deng, Adam J Mead, Laura Stenson, Alice Giustacchini, Sara Duarte, Eleni Giannoulatou, Stephen Taylor, Mohsen Karimi, Christian Scharenberg, Teresa Mortera-Blanco, Iain C Macaulay, Sally-Ann Clark, Ingunn Dybedal, Dag Josefsen, Pierre Fenaux, Peter Hokland, Mette S Holm, Mario Cazzola, Luca Malcovati, Sudhir Tauro, David Bowen, Jacqueline Boultwood, Andrea Pellagatti, John E Pimanda, Ashwin Unnikrishnan, Paresh Vyas, Gudrun Göhring, Brigitte Schlegelberger, Magnus Tobiasson, Gunnar Kvalheim, Stefan N Constantinescu, Claus Nerlov, Lars Nilsson, Peter J Campbell, Rickard Sandberg, Elli Papaemmanuil, Eva Hellström-Lindberg, Sten Linnarsson, Sten Eirik W Jacobsen, None, Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo Cancer Cell. ,vol. 25, pp. 794- 808 ,(2014) , 10.1016/J.CCR.2014.03.036
V Grossmann, U Bacher, C Haferlach, S Schnittger, F Pötzinger, S Weissmann, A Roller, C Eder, A Fasan, M Zenger, M Staller, W Kern, A Kohlmann, T Haferlach, Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics. Leukemia. ,vol. 27, pp. 1940- 1943 ,(2013) , 10.1038/LEU.2013.144
Zhuang Zuo, L. Jeffrey Medeiros, Zhao Chen, Dingsheng Liu, Carlos E. Bueso-Ramos, Rajyalakshmi Luthra, Sa A.Wang, Acute Myeloid Leukemia (AML) with Erythroid Predominance Exhibits Clinical and Molecular Characteristics that Differ from Other Types of AML PLoS ONE. ,vol. 7, pp. e41485- ,(2012) , 10.1371/JOURNAL.PONE.0041485
Michael R Savona, Luca Malcovati, Rami Komrokji, Ramon V Tiu, Tariq I Mughal, Attilio Orazi, Jean-Jacques Kiladjian, Eric Padron, Eric Solary, Raoul Tibes, Raphael Itzykson, Mario Cazzola, Ruben Mesa, Jaroslaw Maciejewski, Pierre Fenaux, Guillermo Garcia-Manero, Aaron Gerds, Guillermo Sanz, Charlotte M Niemeyer, Francisco Cervantes, Ulrich Germing, Nicholas CP Cross, Alan F List, None, An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults Blood. ,vol. 125, pp. 1857- 1865 ,(2015) , 10.1182/BLOOD-2014-10-607341