Acute Myeloid Leukemia (AML) with Erythroid Predominance Exhibits Clinical and Molecular Characteristics that Differ from Other Types of AML
作者： Zhuang Zuo , L. Jeffrey Medeiros , Zhao Chen , Dingsheng Liu , Carlos E. Bueso-Ramos
DOI: 10.1371/JOURNAL.PONE.0041485
关键词: NPM1 、 Leukemia 、 Cytogenetics 、 Erythroid Precursor Cells 、 Cancer research 、 Bone marrow 、 Myeloid leukemia 、 Myeloid 、 Immunology 、 Acute erythroid leukemia 、 Biology 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: The clinical importance of erythroid predominance in bone marrow patients with acute myeloid leukemia (AML) is controversial. These cases represent a heterogeneous group diseases that historically have been classified into different categories. We studied 313 AML and specifically compared the clinical, cytogenetic, molecular features predominance, arbitrarily defined as ≥50% precursors, to without predominance. also assessed 51 high-grade myelodysplastic syndrome (MDS), refractory anemia excess blasts (RAEB). All neoplasms were according World Health Organization classification. With exception therapy-related AML/MDS, presence variously categories was associated survival advantage. In addition, had lower frequency cytogenetic abnormalities well mutations involving NPM1, NRAS FLT3 conclude non-therapy-related setting are much closer those than they other types AML.
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