Mycobacterium tuberculosis infection precipitates SLE in patients from endemic areas

作者: Kanjaksha Ghosh , Manisha Patwardhan , Vandana Pradhan

DOI: 10.1007/S00296-009-0903-X

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摘要: In a cohort of 70 systemic lupus erythematosus (SLE) patients diagnosed over 2 years period, 14 were found to have confirmed antecedent tuberculosis (20.0%) which was 40 times higher (p < 0.001, 95%CI 36.2–48.6) than the prevalence in local population. Demonstration anti-histone antibodies similar proportion SLE with and without anti-TB treatment renal involvement (36 vs. 40%) between drug exposed non-exposed ruled out drugs be causative factors precipitating these history tuberculosis. A 30 pulmonary also studied parallel demonstrate high incidence autoantibodies but no SLE. This study suggests role prior genetically predisposed patients.

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