Disruption of the interaction between amyloid beta peptide and dietary lipids
作者： Laura Mcintire
DOI:
关键词:
摘要: The present invention relates to methods of treating neurodegenerative disorders associated with Alzheimer's disease (AD), Parkinson's (PD) and synucleinopathies, such as dementia Lewy bodies, Down Syndrome (DS) cognitive disorders, multiple system atrophy, rare neuroaxonal dystrophies, Niemann-Pick type C (NPC) Gaucher' s comprising administering an inhibitor disrupt the interaction between Αβ or aS neuronal lipids. further assays for identifying agents that reduce Lastly, compositions intranasal administration fatty acids lipids containing acid acyl chains dietary promoting central nervous health and/or prevention treatment disorders.
lens.org 参考文章(10)
Luc Mercken, Gisela Peraus, Jonathan Rothblatt, Ekkehard Leberer, Edmund Hoppe, Sylvie Dreisler, A-beta-peptide screening ,(2004)
Daryl W. Hochman, John J. Partridge, Bumetanide analogs, compositions and methods of use ,(2014)
Gilbert Rishton, Susan M. Catalano, Nicholas J. Izzo, Compositions and methods for treating neurodegenerative disease ,(2012)
JoAnne McLaurin, Methods of preventing, treating and diagnosing disorders of protein aggregation ,(2004)
Frederick W. Jacobsen, Stephen J. Wood, Anja Leona Biere-Citron, Anti-amyloid antibodies and uses thereof ,(2008)
W. J. Strittmatter, K. H. Weisgraber, D. Y. Huang, L. M. Dong, G. S. Salvesen, M. Pericak-Vance, D. Schmechel, A. M. Saunders, D. Goldgaber, A. D. Roses, Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 8098- 8102 ,(1993) , 10.1073/PNAS.90.17.8098
Marcus OW Grimm, Johanna Kuchenbecker, Sven Grösgen, Verena K Burg, Benjamin Hundsdörfer, Tatjana L Rothhaar, Petra Friess, Martijn C de Wilde, Laus M Broersen, Botond Penke, Mária Péter, László Vígh, Heike S Grimm, Tobias Hartmann, None, Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms Journal of Biological Chemistry. ,vol. 286, pp. 14028- 14039 ,(2011) , 10.1074/JBC.M110.182329
Marie Hennebelle, Emilie Harbeby, Sébastien Tremblay, Raphael Chouinard-Watkins, Fabien Pifferi, Mélanie Plourde, Philippe Guesnet, Stephen C Cunnane, Challenges to determining whether DHA can protect against age-related cognitive decline Clinical Lipidology. ,vol. 10, pp. 91- 102 ,(2015) , 10.2217/CLP.14.61
Abishek Arora, Neeta Bhagat, Insight into the molecular imaging of Alzheimer's disease International Journal of Biomedical Imaging. ,vol. 2016, pp. 7462014- 7462014 ,(2016) , 10.1155/2016/7462014
Nancy C. Stratman, Donald B. Carter, ISOFORM SPECIFIC INTERACTIONS OF APOLIPOPROTEIN E TO AN INTERMEDIATE CONFORMATION OF ALZHEIMER Aβ PEPTIDE ,(2003)