The use of poly(styrene-block-isobutylene-block-styrene) and analogs for long-term implant applications
作者： Danny Bluestein , Leonard Pinchuk , Mark Boden
DOI: 10.1016/B978-0-12-821998-0.00011-9
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摘要: Abstract The invention of poly(styrene-block-isobutylene-block-styrene) (“SIBS”) was the genius Joseph P. Kennedy at University Akron (Akron, OH, United States). SIBS has no cleavable groups, and its predominantly alternating secondary quaternary backbone prevents embrittlement cracking under flexion. This chapter explores four medical devices enabled by SIBS: (1) world’s most successful drug-eluting stent (TAXUS, Boston Scientific Corporate Research, Marlboro, MA, States) releases drug paclitaxel from a carrier that restenosis minimizing smooth muscle cell proliferation; (2) discovery provokes insignificant inflammation encapsulation in eye led to development PRESERFLO MicroShunt (Santen Pharmaceutical Co. Ltd., Osaka, Japan) lower intraocular pressure stop progression vision loss glaucoma; (3) Xi’an EyeDeal Medical Technology Co., Ltd. (Xi’an, China) is developing crosslinked polyisobutylene as an lens eliminates glistening halos; (4) Polynova Cardiovascular Inc. (Stony Brook, NY, testing heart leaflet valve allow percutaneous implantation valves diverse group patients.
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