Role of Granulocyte Colony Stimulating Factor on the Short-Term Outcome of Children with Acute on Chronic Liver Failure.

摘要: Background Acute-on-chronic liver failure (ACLF) results in very high mortality children. We aimed to evaluate the role of granulocyte colony–stimulating factor (GCSF) on short-term outcome children with ACLF a nontransplant unit. Methods Children (aged > 1 year) diagnosed over 15 month period were randomised. Group A was given GCSF therapy along standard medical care (SMC – details supplementary data) and group B only SMC. The evaluated as survival at 30 60 days therapy. Result Thirty-one enrolled, mean age 6.92 ± 4.3yrs. total patients randomised 16 B. overall 54.83%. intervention showed rates 80%, 66.67% 53.3%, whereas control had 43.75%, 37.5% 14, days, respectively. significant benefit noted day 14 (p = 0.043) difference Child-Turcotte-Pugh (CTP) pediatric end-stage disease (PELD) scores two groups. After an initial rise A, counts fell become comparable groups by 60, indicating that effect wears off time. There no survival, median/mean CTP, PELD MCS (Modified Cliff sequential organ assesment (SOFA)) 60. Mean (%) CD 34 + cells level 7 A but statistically insignificant. Conclusion present study shows 5 mcg/kg/day for seems be ineffective improving Studies larger number enrolled longer duration are required. (CTRI/2017/11/010420)