GBR-12909 effect on dopamine outflow depends on phosphorylation in the caudate nucleus of the rat
作者： A. Thümen , F. Qadri , R. Sarkar , A. Moser
DOI: 10.1002/SYN.10124
关键词:
摘要: Modulation of the dopamine (DA) transporter inhibitor GBR-12909 effect on DA release by protein kinases and phosphatases was studied in slices rat caudate nucleus measuring outflow superfusate static chambers. Activation kinase A C markedly enhanced GBR-12909, whereas inhibition H7 reduced effect. Inhibition (PPP) 1 2A okadaic acid did not modify basal DA. However, after addition a dramatic biphasic found when GBR-12909. PPP extracellular levels, while completely abolished In contrast to tetrodotoxin, voltage-activated calcium channel blocker ω-conotoxin MVIIC inhibited effects outflow. Additionally, aCSF devoid increase liberation. These results suggest complex strong influence phosphorylation channel-dependent at low-affinity piperazine binding sites vitro. Synapse 46:72–78, 2002. © 2002 Wiley-Liss, Inc.
sci-hub.se 参考文章(34)
Clemens Neusch, G proteins modulate D2 receptor-coupled K(ATP) channels in rat dopaminergic terminals. Neurochemical Research. ,vol. 25, pp. 1521- 1526 ,(2000) , 10.1023/A:1026620316090
David W. Miller, Elizabeth D. Abercrombie, Role of high-affinity dopamine uptake and impulse activity in the appearance of extracellular dopamine in striatum after administration of exogenous L-DOPA: studies in intact and 6-hydroxydopamine-treated rats. Journal of Neurochemistry. ,vol. 72, pp. 1516- 1522 ,(1999) , 10.1046/J.1471-4159.1999.721516.X
P. A. Shore, Actions of amfonelic acid and other non-amphetamine stimulants on the dopamine neuron. Journal of Pharmacy and Pharmacology. ,vol. 28, pp. 855- 857 ,(2011) , 10.1111/J.2042-7158.1976.TB04078.X
Richard E. Heikkila, Lawrence Manzino, Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: Specific inhibitors of dopamine uptake European Journal of Pharmacology. ,vol. 103, pp. 241- 248 ,(1984) , 10.1016/0014-2999(84)90483-7
Robin A. Huff, Roxanne A. Vaughan, Michael J. Kuhar, George R. Uhl, Phorbol Esters Increase Dopamine Transporter Phosphorylation and Decrease Transport Vmax Journal of Neurochemistry. ,vol. 68, pp. 225- 232 ,(2002) , 10.1046/J.1471-4159.1997.68010225.X
A. Moser, J. Scholz, A. Gänsle, Pituitary adenylate cyclase-activating polypeptide (PACAP-27) enhances tyrosine hydroxylase activity in the nucleus accumbens of the rat Neuropeptides. ,vol. 33, pp. 492- 497 ,(1999) , 10.1054/NPEP.1999.0768
Richard A. Engh, Andreas Girod, Volker Kinzel, Robert Huber, Dirk Bossemeyer, Crystal Structures of Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Isoquinolinesulfonyl Protein Kinase Inhibitors H7, H8, and H89 Journal of Biological Chemistry. ,vol. 271, pp. 26157- 26164 ,(1996) , 10.1074/JBC.271.42.26157
C.A. Ayala, E.H. Jaffe, Pharmacological modulation of endogenous dopamine and DOPAC outflow from nucleus accumbens Neuropharmacology. ,vol. 32, pp. 1401- 1409 ,(1993) , 10.1016/0028-3908(93)90037-4
Peter H. Andersen, The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action European Journal of Pharmacology. ,vol. 166, pp. 493- 504 ,(1989) , 10.1016/0014-2999(89)90363-4
Paul E.M. Phillips, Jonathan A. Stamford, Differential recruitment of N-, P- and Q-type voltage-operated calcium channels in striatal dopamine release evoked by ‘regular’ and ‘burst’ firing Brain Research. ,vol. 884, pp. 139- 146 ,(2000) , 10.1016/S0006-8993(00)02958-9