G proteins modulate D2 receptor-coupled K(ATP) channels in rat dopaminergic terminals.
作者： Clemens Neusch
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摘要: The presynaptic dopamine (DA) D2 receptor-mediated regulation of ATP-sensitive potassium (K+ ATP) channels was examined in slices the rat caudate-putamen. When were incubated with specific receptor antagonist (−)-sulpiride (SLP), a concentration-dependent increase extracellular DA release observed. SLP-induced enhancement completely antagonized by coincubation K+ ATP channel opener diazoxide (DIA). Treatment agonist quinpirole (QUI) almost inhibited outflow induced blocker butanedione-monoxime (BDM). Coincubation SLP and guanosine triphosphate (GTP) or its non-hydrolizable analogue guanylyl-5′-imidodiphosphate [Gpp(NH)p], significantly reduced effect on levels. Furthermore, we observed that BDM-induced markedly G protein activators suggesting an additional receptor-independent gating. Our results suggest PTX-sensitive proteins are involved signal transduction between receptors channels. can be modulated mechanism activators.
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