Dopamine receptor regulation of Ca2+ levels in individual isolated nerve terminals from rat striatum: comparison of presynaptic D1-like and D2-like receptors.
作者： Jianlin Wu , John. J. Dougherty , Robert A. Nichols
DOI: 10.1111/J.1471-4159.2006.03901.X
关键词: Alpha-4 beta-2 nicotinic receptor 、 Internal medicine 、 Biology 、 Receptor antagonist 、 Voltage-dependent calcium channel 、 Synaptosome 、 Receptor 、 Endocrinology 、 Agonist 、 Quinpirole 、 Dopamine receptor
摘要: We have directly observed the effects of activating presynaptic D1-like and D2-like dopamine receptors on Ca2+ levels in isolated nerve terminals (synaptosomes) from rat striatum. R-(+)-SKF81297, a selective receptor agonist, (–)-quinpirole, induced increases different subsets individual striatal synaptosomes. The SKF81297- quinpirole-induced were blocked by R-(+)-SCH23390, antagonist, (–)-sulpiride, respectively. or inhibited following blockade voltage-gated calcium channels sodium channels. In larger subset synaptosomes, quinpirole decreased baseline Ca2+. Quinpirole also veratridine-induced intrasynaptosomal level. Immunostaining confirmed expression D1, D5, D2 D3 receptors, but not D4 receptors. array neurotransmitter phenotypes endings expressing varied for each subtype. These results suggest that induce via Na+ channel-mediated membrane depolarization, which, turn, induces opening reduce terminal consistent with predominant action striatum being inhibitory.
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