ATP-sensitive potassium channels regulate in vivo dopamine release in rat striatum.
作者： Zhu Dawn Xiao-Dong , Sullivan James P. , Brioni Jorge D.
DOI: 10.1254/JJP.79.59
关键词:
摘要: Abstract ATP-sensitive K+ channels (KATP) are distributed in a variety of tissues including smooth muscle, cardiac and skeletal pancreatic β-cells neurons. Since KATP present the nigrostriatal dopamine (DA) pathway, effect potassium-channel modulators on release DA striatum conscious, freely-moving rats was investigated. The extracellular concentration significantly decreased by KATP-channel opener (−)-cromakalim but not diazoxide. (−)-Cromakalim effective at 100 1000 μM concentrations, maximum decrease 54% below baseline. d-Amphetamine increased levels doses 0.75 1.5 mg/kg, s.c. with 770% increase. (—)-Cromakalim had no d-amphetamine-induced release, while glyburide, blocker, potentiated effects low dose d-amphetamine. These data indicate that dopaminergic terminals modulate basal as well evoked DA.
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