Effects of indomethacin on energy metabolism in rat jejunal tissue in vivo
作者： Molly JACOB , Ingvar BJARNASON , Robert J. SIMPSON
DOI: 10.1042/CS1020541
关键词:
摘要: The non-steroidal anti-inflammatory drugs (NSAIDs) are a widely used group of in clinical medicine. However, their propensity to cause gastrointestinal damage limits utility. pathogenesis this toxicity is not well established. It has been postulated that an early event the development eect these on mitochondrial function. present paper sets out evaluate eects indomethacin, commonly NSAID, energy metabolism vivo. Indomethacin was administered male Sprague‐Dawley rats, either intrajejunally or orally, and indices function were determined. parameters chosen for purpose oxygen uptake by, lactate levels charge jejunal tissue. Oxygen by tissue unaected at 1 3 h after dosing gavage with indomethacin. drug significantly aected lactate/pyruvate ratio (but h) oral dosing. Eects indomethacin jejunum incubated ex vivo found be reversible. data suggest aects vivo, but compensatory changes glycolytic rate maintain charge.
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