A study of the effects of indometacin on liver mitochondria from rats, mice and humans
作者： M. Jacob , I. Bjarnason , S. Rafi , J. Wrigglesworth , R. J. Simpson
DOI: 10.1046/J.1365-2036.2001.01095.X
关键词: Oxidative phosphorylation 、 Mechanism of action 、 Dinitrophenol 、 Adenosine triphosphate 、 Toxicity 、 Indometacin 、 Internal medicine 、 Biology 、 Enzyme inhibitor 、 Endocrinology 、 Mitochondrion 、 Pharmacology (medical)
摘要: Background: A part of the mechanism gastrointestinal toxicity exhibited by non-steroidal anti-inflammatory drugs is believed to involve uncoupling mitochondrial oxidative phosphorylation. Most previous studies have used rat liver mitochondria. There little information on effects mitochondria from other species. Aim: To study effect indometacin isolated rats, mice and humans. Methods: We studied respiration adenosine triphosphate synthesis humans. Its were compared with those dinitrophenol, a classical uncoupler. Results: Indometacin uncoupled phosphorylation at low concentrations (P < 0.05) inhibited high (P < 0.01) in all three species. Adenosine was, however, more sensitive dinitrophenol or lower mouse human (P < 0.05). Conclusions: The current shows that acts as an inhibitory uncoupler It also demonstrates responses rat, are broadly similar.
core.ac.uk
sci-hub.se 参考文章(21)
M. Ligumsky, M. Sestieri, F. Karmeli, J. Zimmerman, E. Okon, D. Rachmilewitz, Rectal administration of nonsteroidal antiinflammatory drugs. Effect on rat gastric ulcerogenicity and prostaglandin E2 synthesis. Gastroenterology. ,vol. 98, pp. 1245- 1249 ,(1990) , 10.1016/0016-5085(90)90340-7
Guy C. Brown, Chris E. Cooper, David G. Nicholls, Mitochondria and Cell Death ,(1999)
Moshe Ligumsky, Elizabeth M. Golanska, Duane G. Hansen, Gordon L. Kauffman, Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat Gastroenterology. ,vol. 84, pp. 756- 761 ,(1983) , 10.1016/0016-5085(83)90143-9
Guido Kroemer, Naoufal Zamzami, Santos A. Susin, Mitochondrial control of apoptosis Immunology Today. ,vol. 18, pp. 44- 51 ,(1997) , 10.1016/S0167-5699(97)80014-X
Lenard M. Lichtenberger, Zu-Mo Wang, Jimmy J. Romero, Carlos Ulloa, Joseph C. Perez, Marie-Noëlle Giraud, José C. Barreto, Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury Nature Medicine. ,vol. 1, pp. 154- 158 ,(1995) , 10.1038/NM0295-154
Taher Mahmud, Sue S. Rafi, David L. Scott, John M. Wrigglesworth, Ingvar Bjarnason, Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation Arthritis & Rheumatism. ,vol. 39, pp. 1998- 2003 ,(1996) , 10.1002/ART.1780391208
Juan Reyes, Dale J. Benos, Changes in interfacial potentials induced by carbonylcyanide phenylhydrazone uncouplers: possible role in inhibition of mitochondrial oxygen consumption and other transport processes. Membrane biochemistry. ,vol. 5, pp. 243- 268 ,(1984) , 10.3109/09687688409150281
Somasundaram, Sigthorsson, Simpson, Watts, Jacob, Tavares, Rafi, Roseth, Foster, Price, Wrigglesworth, Bjarnason, Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Alimentary Pharmacology & Therapeutics. ,vol. 14, pp. 639- 650 ,(2000) , 10.1046/J.1365-2036.2000.00723.X
S. Somasundaram, H. Hayllar, S. Rafi, J. M. Wrigglesworth, A. J. S. Macpherson, I. Bjarnason, The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis. Scandinavian Journal of Gastroenterology. ,vol. 30, pp. 289- 299 ,(1995) , 10.3109/00365529509093280
S. S. ADAMS, R. COBB, A possible basis for the anti-inflammatory activity of salicylates and other non-hormonal anti-rheumatic drugs. Nature. ,vol. 181, pp. 773- 774 ,(1958) , 10.1038/181773B0