Tanis: A Link Between Type 2 Diabetes and Inflammation?

摘要: Here we describe a novel protein, which have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus , unique polygenic animal model of the metabolic syndrome, Tanis expressed liver inverse proportion to circulating glucose ( P = 0.010) insulin levels 0.004) direct with plasma triglyceride concentrations 0.007). Hepatic gene expression was markedly increased (3.1-fold) after 24-h fast diabetic but not nondiabetic P. obesus. addition, inhibited cultured hepatocytes 0.006) as well several other cell types 0.001–0.011). Thus, seems be regulated by dysregulated state. Yeast-2 hybrid screening identified serum amyloid A (SAA), an acute-phase inflammatory response interacting protein this confirmed Biacore experiments. SAA proteins been focus recent attention risk factors for cardiovascular disease, contend its interaction may provide mechanistic link among diabetes, inflammation, disease.