Roles of glial cells in schizophrenia: possible targets for therapeutic approaches.

摘要: Glial cells consisting of oligodendrocytes, astrocytes, microglia, and NG2 positive are major cell populations in the central nervous system, number-wise. They function as effectors modulators neurodevelopment through a wide variety neuron-glial interactions brain development functions. can be affected by both genetic environmental factors, leading to their dysfunctions supporting neuronal These turn affect cells, causing alterations at circuitry level that manifest behavioral characteristics associated with schizophrenia late teens-early twenties. also involved neuroinflammatory processes, which sometimes have deleterious effects on normal development. If glial involvement plays significant roles schizophrenia, processes involving become possible therapeutic targets for schizophrenia. A number known antipsychotics shown beneficial but other drugs targeting functions may The latter taken into consideration future drug