Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.

摘要: Profound white matter abnormalities have repeatedly been described in schizophrenia, which involve the altered expression of numerous oligodendrocyte-associated genes. Transcripts disrupted-in-schizophrenia 1 (DISC1) gene, a key susceptibility factor recently shown to be expressed by oligodendroglial cells and negatively regulate oligodendrocyte differentiation maturation. To learn more about putative role(s) oligodendroglia-associated DISC1 we analyzed density DISC1-immunoreactive oligodendrocytes fronto-parietal postmortem brains patients with schizophrenia. Compared controls (N = 12) cases undifferentiated/residual schizophrenia (N = 6), there was significantly increased DISC1-expressing glial paranoid (N = 12), unlikely resulted from neuroleptic treatment. Pathophysiologically, over-expression protein(s) might add reduced levels two myelin markers, 2',3'-cyclic-nucleotide 3'-phosphodiesterase basic protein Moreover, it contribute cell cycle as well deficits maturation found