Changes in CREB-phosphorylation during recovery from major depression.
作者： Jakob M Koch , Susanne Kell , Dunja Hinze-Selch , Josef B Aldenhoff
DOI: 10.1016/S0022-3956(02)00056-0
关键词:
摘要: For decades psychiatrists have been looking for biological state markers measurable by easy blood test in order to follow up and predict early on treatment response patients with major depression. In the present study we investigated whether or not measuring CREB (cAMP-response-element-binding-protein) phosphorylation peripheral T lymphocytes is a marker of response. an ubiquitous key-element intracellular signal transduction cascades its transcriptional activity depends at Ser-133. Several studies animals demonstrated that up-regulated antidepressant treatment. Therefore, it has hypothesized exerts therapeutic effect this mechanism. study, CREB-phosphorylation T-lymphocytes 20 before end week one two either psychopharmacological psychotherapeutic After weeks, 15 fulfilled criteria (i.e. 30% reduction HAMD score compared baseline), whereas five did not. two, responders showed significant increase (P = 0.018) non-responders. This was true all regimen. conclusion, these results indicate first time might be molecular
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