Cyclic AMP modulates the response of central nervous system glia to fibroblast growth factor-2 by redirecting signalling pathways.
作者： Nadhim Bayatti , Jürgen Engele
DOI: 10.1046/J.1471-4159.2001.00464.X
关键词:
摘要: Fibroblast growth factor-2 (FGF-2) acts as both a potent mitogen and differentiation factor for CNS glia. In the present study, we provide evidence that intracellular cAMP determines proliferation-differentiation decision of astroglia to FGF-2 by either facilitating signalling extracellular signal-related protein kinase (ERK) or response element binding (CREB). Pharmacologically increasing levels in cultured cortical treatment with dbcAMP forskolin attenuated FGF-2-induced ERK phosphorylation glial cell proliferation. Similarly, proliferation was presence MEK inhibitor, PD98059, thus, confirming direct correlation between activation On other hand, increases prolonged CREB subsequently potentiated element-dependent transcription immediate early gene, c-fos. Moreover, effects on time-course FGF-2-dependent were mimicked suggesting cAMP-induced redirection FGF-2-signalling is linked RAF-MEK-ERK pathway.
sci-hub.se 参考文章(37)
E Lalli, P Sassone-Corsi, OM Rivero-Lezcano, JH Sameshima, A Marcilla, KC Robbins, M Köhler, HC Kornau, PH Seeburg, E Angotti, E Mele, F Costanzo, EV Avvedimento, VV Filonenko, MP Deutscher, BP Crider, XS Xie, DK Stone, F Tokunaga, T Goto, T Koide, Y Murakami, S Hayashi, T Tamura, K Tanaka, A Ichihara, EH Koo, SL Squazzo, CC Correll, L Ng, PA Edwards, A Di Donato, V Cafaro, G D'Alessio, D Tantin, M Carey, JA Blaho, C Mitchell, B Roizman, CG Wilde, JJ Seilhamer, M McGrogan, N Ashton, JL Snable, JC Lane, SR Leong, MB Thornton, KL Miller, RW Scott, NX Qian, M Russell, AM Buhl, GL Johnson, M Yagi, S Edelhoff, CM Disteche, GJ Roth, TY Heinonen, RE Pearlman, Z Li, S Matsuoka, LV Hryshko, DA Nicoll, MM Bersohn, EP Burke, RP Lifton, KD Philipson, A Zhou, RE Mains, S Davail, G Feller, E Narinx, C Gerday, A van Heerden, KS Browning, F Madueño, SA Bradshaw, JC Gray, M Le Romancer, F Reyl-Desmars, Y Cherifi, C Pigeon, S Bottari, O Meyer, MJ Lewin, R Piédagnel, D Prié, R Cassingéna, PM Ronco, B Lelongt, K Adachi, P Konitzer, CG Paulraj, S Surrey, BR Henderson, E Menotti, C Bonnard, LC Kühn, F Pries, AJ van den Wijngaard, Signal transduction and gene regulation: the nuclear response to cAMP. Journal of Biological Chemistry. ,vol. 269, pp. 17359- 17362 ,(1994) , 10.1016/S0021-9258(17)32442-0
Matthew F. McManus, Li-Chun Chen, Inmaculada Vallejo, Mario Vallejo, Astroglial Differentiation of Cortical Precursor Cells Triggered by Activation of the cAMP-Dependent Signaling Pathway The Journal of Neuroscience. ,vol. 19, pp. 9004- 9015 ,(1999) , 10.1523/JNEUROSCI.19-20-09004.1999
Györgyi Szebenyi, John F. Fallon, Fibroblast Growth Factors as Multifunctional Signaling Factors International Review of Cytology-a Survey of Cell Biology. ,vol. 185, pp. 45- 106 ,(1999) , 10.1016/S0074-7696(08)60149-7
F Gomez-Pinilla, L Vu, CW Cotman, Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo The Journal of Neuroscience. ,vol. 15, pp. 2021- 2029 ,(1995) , 10.1523/JNEUROSCI.15-03-02021.1995
Kristin Roovers, Richard K. Assoian, Integrating the MAP kinase signal into the G1 phase cell cycle machinery. BioEssays. ,vol. 22, pp. 818- 826 ,(2000) , 10.1002/1521-1878(200009)22:9<818::AID-BIES7>3.0.CO;2-6
Azad Bonni, David D. Ginty, Henryk Dudek, Michael E. Greenberg, Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals Molecular and Cellular Neuroscience. ,vol. 6, pp. 168- 183 ,(1995) , 10.1006/MCNE.1995.1015
KARL SCHILLING, TOM CURRAN, JAMES I. MORGAN, Fosvergnügen. The excitement of immediate-early genes. Annals of the New York Academy of Sciences. ,vol. 627, pp. 115- 123 ,(1991) , 10.1111/J.1749-6632.1991.TB25917.X
Fu-Chin Liu, Ann M Graybiel, Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum Neuron. ,vol. 17, pp. 1133- 1144 ,(1996) , 10.1016/S0896-6273(00)80245-7
J. Engele, K. Schilling, Growth factor-induced c-fos expression defines distinct subsets of midbrain dopaminergic neurons. Neuroscience. ,vol. 73, pp. 397- 406 ,(1996) , 10.1016/0306-4522(96)00045-0
Richard J. Smeyne, Karl Schilling, Linda Robertson, Daniel Luk, John Oberdick, Tom Curran, James I. Morgan, Fos-IacZ transgenic mice: Mapping sites of gene induction in the central nervous system Neuron. ,vol. 8, pp. 13- 23 ,(1992) , 10.1016/0896-6273(92)90105-M