Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.

摘要: A key but poorly studied domain of sphingolipid functions encompasses endocytosis, exocytosis, cellular trafficking, and cell movement. Recently, the ezrin, radixin moesin (ERM) family proteins emerged as novel potent targets regulated by sphingolipids. ERMs are structural linking actin cytoskeleton to plasma membrane, also forming a scaffold for signaling pathways that used proliferation, migration invasion, division. Opposing bioactive ceramide sphingosine-1-phosphate (S1P), contribute ERM regulation. S1P robustly activates whereas potently deactivates via phosphorylation/dephosphorylation, respectively. This recent dimension cytoskeletal regulation sphingolipids opens up new avenues target dynamics, provides further understanding some unexplained biological effects mediated In addition, these studies providing inroads into defining basic mechanisms action review describes current cytoskeleton, it biologies in which have been involved, finally how two large fields started converge. article is part Special Issue entitled New Frontiers Sphingolipid Biology.