Calcium Dependence of Hypoosmotically Induced Potassium Release in Cultured Astrocytes

摘要: A major mechanism in cell volume regulation after hypoosmotic stress is K+ release. Our studies show that astrocytes, release during a Ca(2+)-dependent process. Agents increase intracellular Ca2+, such as ionomycin and ouabain, potentiated hypoosmotically stimulated release, while compounds block Ca2+ entry stress, nimodipine, bepridil, MK- 801, inhibited Similarly, chelation of blocked induced Caffeine U-73122 also efflux under conditions, suggesting from Ca(2+)-induced stores inositol trisphosphate-sensitive play role the Blocking activity calmodulin, CaM kinase, attenuated findings indicate extracellular key activation conditions thus regulation.