An update on molecular biology and drug resistance mechanisms of multiple myeloma

摘要: Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM commonly seen in men and African-American population. There are several factors to this, such as obesity, environmental factors, family history, genetic monoclonal gammopathies undetermined significance (MGUS) that have been implicated potentially etiologic. Development involves series complex molecular events, including chromosomal abnormalities, oncogene activation growth factor dysregulation. Chemotherapy used treatment strategy MM. However, difficult disease treat because its marked resistance chemotherapy. has shown be multidrug (MDR)-negative at diagnosis associated with high incidence MDR expression relapse. This review deals aspects MM, drug mechanisms during also possible new applications for overcoming resistance.