Conformational Aspects of Enzyme Regulation

摘要: Publisher Summary This chapter discusses the molecular models that attempt to provide a correlation of kinetic properties protein with its structural architecture. Recent reviews have covered other aspects regulatory control—such as interaction metabolic pathways, various types end product inhibition, and evidence for conformational changes—should be consulted these subjects. Two comprehensive theories capable explaining allosteric regulation in quantitative terms been proposed. describes presents an evaluation their present status future use. The control enzyme action can occur number ways—by by depletion substrate, failure synthesize enzyme, covalent modification, or destruction enzyme. Although all mechanisms are available used cell, perhaps most ubiquitous efficient process complex sequences is use effector molecules not themselves consumed reaction. When it was recognized flexibility essential feature action, way paved understanding at level activity specific led turn elaboration concept distinct separate site, which played role feedback so prevalent bacterial systems.