Footprints of directional selection in wild atlantic salmon populations: Evidence for parasite-driven evolution?

摘要: Mechanisms of host-parasite co-adaptation have long been interest in evolutionary biology; however, determining the genetic basis parasite resistance has challenging. Current advances genome technologies provide new opportunities for obtaining a genome-scale view action parasite-driven natural selection wild populations and thus facilitate search specific genomic regions underlying inter-population differences pathogen response. European Atlantic salmon (Salmo salar L.) exhibit variance susceptibility levels to ectoparasite Gyrodactylus salaris Malmberg 1957, ranging from extreme susceptibility, are therefore good model studying evolution virulence resistance. However, distinguishing molecular signatures drift environment-associated small such as land-locked presents challenge, specifically pathogen-driven selection. We used novel genome-scan analysis approach that enabled us i) identify signals affected by varying ii) separate potentially selected loci into categories (G. salaris)-driven acting upon other environmental characteristics. A total 4631 single nucleotide polymorphisms (SNPs) were screened 12 different northern populations. identified three selection, well presumably salinity-driven directional Functional annotation candidate SNPs is consistent with role detected immune defence and, implicitly, osmoregulation. These results insights will enable future searches genes involved.