Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies
作者： Alexander R. Ball , Yen-Yun Chen , Kyoko Yokomori
DOI: 10.1016/J.BBAGRM.2013.11.002
关键词:
摘要: Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin modulate higher-order organization. mediate sister chromatid cohesion cellular long-distance interactions affecting genome maintenance gene expression. Discoveries mutations in cohesin's subunits its regulator proteins human developmental disorders, so-called "cohesinopathies," reveal crucial roles for cohesins development growth differentiation. In this review, we discuss the latest findings concerning functions architecture organization regulation new insight gained from studies cohesinopathies. This article is part a Special Issue entitled: Chromatin epigenetic animal development.
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sci-hub.se 参考文章(215)
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