The potential roles of dopamine in malignant glioma
作者： Yu-Long Lan , Xun Wang , Jin-Shan Xing , Jia-Cheng Lou , Xiao-Chi Ma
DOI: 10.1007/S13760-016-0730-2
关键词:
摘要: Despite the numerous promising discoveries in contemporary cancer research and emerging innovative treatment strategies, global burden of malignant glioma is expected to increase, partially due its poor prognosis human aging. Dopamine, a monoamine catecholamine neurotransmitter, currently regarded as an important endogenous regulator tumor growth. Dopamine may be for brain tumors could impact pathogenesis by regulating angiogenesis vasculogenesis. Additionally, dopamine might exert anti-glioma, cytotoxic effect modulating apoptosis autophagy. receptors are also known influence immune system, it related glioma. increase efficacy anti-cancer drugs. Here, we review potential roles further identify previously unknown function potent Currently, precise mechanisms regarding protective on poorly understood. However, our experimental results strongly emphasize importance this topic future investigations.
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