摘要: Abstract Adipose tissue represents a critical component in healthy energy homeostasis. It fulfills important roles whole‐body lipid handling, serves as the body9s major storage compartment and insulation barrier, secretes numerous endocrine mediators such adipokines or lipokines. As consequence, dysfunction of these processes adipose compartments is tightly linked to severe metabolic disorders, including obesity, syndrome, lipodystrophy, cachexia. While studies have addressed causes consequences obesity‐related hypertrophy hyperplasia for health, pathways mechanisms (involuntary) loss well its systemic are far less understood. In this review, we discuss current understanding conditions wasting review microenvironmental determinants adipocyte (dys)function related pathophysiologies.
utsystem.edu参考文章(214)
Trew Ja, Begg Rw, In vitro incorporation of acetate-1-C14 into adipose tissue from normal and tumor-bearing rats. Cancer Research. ,vol. 19, pp. 1014- 1019 ,(1959)
Mustapha Maachi, Willy Rozenbaum, Anne Lombes, Jean-Philippe Bastard, Jacqueline Capeau, Pierre-Marie Girard, Hubert Vidal, Véronique Jan, Marielle Baudrimont, Minji Kim, Philippe Levan, Pascale Cervera, Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients. Antiviral Therapy. ,vol. 9, pp. 555- 564 ,(2004)
Michele Alves, Emidio Matos Neto, Linda Maximiliano, Paulo Alcantara, Jose Otoch, Miguel Batista, Marilia Seelaender, None, ADIPOSE TISSUE EXTRACELLULAR MATRIX REMODELLING IN CANCER CACHEXIA The FASEB Journal. ,vol. 29, ,(2015)
Justin I Odegaard, Ajay Chawla, Type 2 responses at the interface between immunity and fat metabolism. Current Opinion in Immunology. ,vol. 36, pp. 67- 72 ,(2015) , 10.1016/J.COI.2015.07.003
Miguel L Batista Jr, Felipe S Henriques, Rodrigo X Neves, Mireia R Olivan, Emídio M Matos‐Neto, Paulo SM Alcântara, Linda F Maximiano, José P Otoch, Michele J Alves, Marília Seelaender, None, Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients. Journal of Cachexia, Sarcopenia and Muscle. ,vol. 7, pp. 37- 47 ,(2016) , 10.1002/JCSM.12037
Iichiro Shimomura, Robert E. Hammer, Shinji Ikemoto, Michael S. Brown, Joseph L. Goldstein, Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature. ,vol. 401, pp. 73- 76 ,(1999) , 10.1038/43448
Mathias Fasshauer, Matthias Blüher, Adipokines in health and disease Trends in Pharmacological Sciences. ,vol. 36, pp. 461- 470 ,(2015) , 10.1016/J.TIPS.2015.04.014
Nivedita Patni, Abhimanyu Garg, Congenital generalized lipodystrophies—new insights into metabolic dysfunction Nature Reviews Endocrinology. ,vol. 11, pp. 522- 534 ,(2015) , 10.1038/NRENDO.2015.123
T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, T. Kadowaki, The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Medicine. ,vol. 7, pp. 941- 946 ,(2001) , 10.1038/90984
Gustavo Abreu-Vieira, Alexander W. Fischer, Charlotte Mattsson, Jasper M.A. de Jong, Irina G. Shabalina, Mikael Rydén, Jurga Laurencikiene, Peter Arner, Barbara Cannon, Jan Nedergaard, Natasa Petrovic, Cidea improves the metabolic profile through expansion of adipose tissue Nature Communications. ,vol. 6, pp. 7433- 7433 ,(2015) , 10.1038/NCOMMS8433